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Bharat B. Biswal教授——Toward Task Connectomics: Examining Whole-Brain Task Modulated Connectivity in Different Task Domains

发布时间:2018-05-14 来源:本站原创 作者:本站编辑   浏览次数:

报告题目: 务态脑连学:揭示不同任务调型下的全脑连分析

Toward Task Connectomics: Examining Whole-Brain Task Modulated Connectivity in Different Task Domains

报告人:Bharat B. Biswal教授

报告时间:2018522日上午9:30

报到地点:心理学部213

报告人简历:Bharat B. Biswal教授为美国新泽西理工学院生物医学工程系教授;是国际顶级脑成像专家,汤森路透全球高被引科学家World's Most Influential Scientific Minds”入选者(2015),2017年入选中国外专千人计划并同时加入电子科技大学生命科学与技术学院。Biswal教授是静息态脑功能磁共振成像的鼻祖,率先提出了静息态脑功能活动概念,建立了用功能磁共振(fMRI)研究大脑静息态的方法(resting state fMRI)。迄今所发表的系列论文被应用已超过5万次,提出静息态脑功能概念的原始论文迄今单篇被引用4千余次(Biswal et al “Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.” MRM 34 (4) 537-541. ),所开的静息态脑成像研究方法已在正常功能和疾病研究中得到广泛用。

Abstract: Human brain anatomical and resting-state functional connectivity have been comprehensively portrayed using MRI, which are termed anatomical and functional connectomes.  A systematic examination of tasks modulated whole brain functional connectivity, which we term as task connectome, is still lacking.  We analyzed six block-designed and one event-related designed functional MRI data, and examined whole-brain task modulated connectivity in various task domains, including emotion, reward, language, relation, social cognition, working memory, and inhibition.  By using psychophysiological interaction between pairs of regions from the whole brain, we identified statistically significant task modulated connectivity in four tasks between their experimental and respective control conditions.  Task modulated connectivity was found not only between regions that were activated during the task but also regions that were not activated or deactivated, suggesting a broader involvement of brain regions in a task than simply localized regional activations.  Decreased functional connectivity was observed in all the four tasks and sometimes reduced connectivity was even between regions that were both activated during the task.  This suggests that brain regions that are activated together do not necessarily work together.  The current study demonstrates the comprehensive task connectomes of four tasks, and suggested complex relationships between regional activations and connectivity changes.