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陈焕新

发布时间:2015-03-08 来源:本站原创 作者:本站编辑   浏览次数:

 

简介

陈焕新,教授,博士生导师,西南大学心理学部转化研究中心主任。1995年中国科学院上海生理研究所获博士学位。1996年至2000年,先后于瑞典哥德堡大学和美国Brandeis大学从事突触可塑性方面的博士后研究。2001年至2014年任职于佛罗里达大学神经外科,神经内科系McKnight 脑科学研究所任助理研究员和研究员。期间于2007年获中科院心理研究所百人计划,973课题负责人。2012年至2013年在美国密苏里大学医院神经内科任住院医生。2015年西南大学以杰出人才引进。长期从事大脑高级功能,突触可塑性,应激和神经精神疾病机理,特别是大脑皮层各类GABA能神经元功能及神经环路的研究,在国际著名刊物发表多篇论文,被引用上千次。


研究兴趣:

应激(压力)的脑神经环路及调控机制,特别是各类GABA能神经元在调控机制中的作用;与应激密切相关的神经精神类疾病的产生机制,包括抑郁、焦虑、精神分裂症、老年痴呆等;神经环路中不同类型突触的发育和可塑性的分子机制。主要研究方法有条件性基因敲除和嵌入、膜片钳、光遗传学、细胞培养、组织化学及多种行为学测试。



联系地址

西南大学心理学院

北碚区天生路2 400715

电话 18182208105

邮箱 chenhx354657@qq.com  huanxin@yahoo.com


教育经历

1992/9-1995/6 中国科学院上海生理研究所,神经生物学,博士

1986/9-1989/6 西安交通大学医学院,神经生理学,硕士

1981/9-1986/6 兰州大学医学院,医学,医学学士


工作经历

2015/1- 教授,西南大学心理学部

2010/11-2014/12 助理研究员及研究员,佛罗里达大学脑科学研究,神经内科,神经外科

2012/6-2013/5 住院医师,密苏里大学医院神经内科

1997/8-2000/10 博士后,美国Brandies 大学,神经生物系

1995/11-1997/7 博士后,瑞典哥德堡大学生理系

1989/9-1992/8 讲师,西安医学院生理系


专业会员

美国神经科学会

癫痫学会

中国神经科学会

中国心理科学会

中国身心科学会


发表文章

H.-X. Chen and J.-H. Wang (1995). Potentiation of synaptic transmission induced by DAG/PS and its mutual occlusion with long-term potentiation in rat hippocampal slices. Chin.J.Physiol.Sci. 11(2): 97-102.(Corresponding author).


M. Pananceau, H.-X. Chen and B. Gustafsson (1997). Long-term potentiation induced by single volley activation: a mechanism for bicuculine-induced enhancement of the synaptic field potentials in the CA1 hippocampal region.Neuroscience 79(1): 95-101.


M. Pananceau, H.-X. Chen and B. Gustafsson (1998). Short-term facilitation evoked during brief afferent tetani is not altered by long-term potentiation in the guineapig hippocampal CA1 region. Journal of Physiology (London). 508(2): 503-514.


H.-X. Chen, Eric Hanse, Marc Pananceau and Bengt Gustafsson (1998). Distinct expressions for synaptic potentiation induced by calcium through voltage-gated calcium and NMDA receptor channels in the hippocampal CA1 region. Neuroscience 86(2): 415-422.


H.-X. Chen, N. Otmakhov and J. Lisman (1999). Requirements for LTP induction by Pairing in hippocampal CA1 pyramidal cells. J. Neurophysiol. 82: 526-532.


H.-X. Chen, N. Otmakhov, S. Strack, R. J. Colbran, and J.E. Lisman (2001). Is persistent activity of calcium/calmodulin-dependent kinase required for the maintenance of LTP? J. Neurophysiol. 2001 85: 1368-1376


H.-X. Chen and Steven Roper(2003). Reduction of spontaneous inhibitory synaptic activity in experimental heterotopic gray matter. J. Neurophysiol. 89: 150-158.


TM Shepherd, ED Wirth III, PE Thelwall, H.-X. Chen, SN Roper and SJ Blackband (2003). Non-monoexponential diffusion measurements in perfused human hippocampal slices undergoing tonicity changes. Magnetic Resonance in Medicine 49:856-863.


H.-X. Chen and Steven Roper (2003). PKA and PKC enhance excitatory synaptic transmission in human dentate gyrus. J. Neurophysiol. 89: 2482-2488.


T Nakatsuka٭, H.-X. Chen٭, S. Roper and, JG. Gu (2003) Cannabinoid receptor-l activation suppresses inhibitory synaptic activity in human dentate gyrus.(٭ Contributed equally). Neuropharmacology. 45:116-121.


H.-X. Chen and Steven Roper (2004). Tonic Activity of Metabotropic Glutamate Receptors is Involved in Developmental Modification of Short-term Plasticity in the Neocortex. J Neurophysiol 92: 838-844.

ED Laywell, SM Kearns, T Zhong, KL Chen, J Deng, H.-X. Chen, SN Roper and A Steindler (2005). Phenotypic Fluidity: Neurons Transition into Astrocytes through a Hybrid Asteron Phenotype in Novel Cultures of Cerebellar Stem/Progenitor Cells. J. Comp. Neurol. 493:321-333.


Hui Xiang, Huan-Xin Chen, Xin-Xin Yu, Michael A King, and Steven N. Roper(2006) Reduced Excitatory Drive in Interneurons in an Animal Model of Cortical Dysplasia J Neurophysiol. 96:569-578. (Corresponding author).


Katrin Goetz, Bjorn Scheffler, H.-X. Chen, Shanshan Wang, Hui Xiang, Oliver Brustle, Steve N.Roper, and Dennis A. Steindler(2006). Substrate Interactions Direct Fate Choice And Specification Of Neural Precursors Derived From Embryonic Stem Cells. PNAS USA 103: 11063-8.


Ke-Hong Ding, Qing Zhong, Ding Xie, Huan-Xin Chen, Mary Anne Della-Fera, Roni J. Bollag, Wendy B, Bollag, Ravinder Gujral, Baolin Kang, Supriya Sridhar, Clifton Baile, Walton Curl and Carlos M. Isales(2006). Effects of glucose-dependent insulinotropic peptide on behavior. Peptides 27: 2750-2755.


Noah M. Walton, Benjamin M. Sutter, Huan-Xin Chen, Lung-Ji Chang, Steven N. Roper, Bjorn Scheffler, and Dennis A. Steindler(2006). Derivation and large-scale expansion of multipotent astroglial neural progenitors from adult human brain . Development 133, 3671-3681.


H.-X. Chen, Hui Xiang and Steven Roper(2007). Altered development of short-term plasticity in experimental cortical dysplasia. Epilepsia, 48: 141-148(Corresponding author).


Qizhi Zhang, Zhao Liu, Paul R. Carney, Zhen Yuan, Huanxin Chen, Steven N. Roper, and Huabei Jiang(2008). Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography.Phys. Med. Biol. 53 1921-1931.


Zhou FW, Chen HX, Roper SN(2009) Balance of inhibitory and excitatory synaptic activity is altered in fast-spiking interneurons in experimental cortical dysplasia. Journal of Neurophysiology.102(2): 2514-2525.

Chen HX, Jiang M, Akakin D, Roper SN(2009). Long-term potentiation of excitatory synapses on neocortical somatostatin-expressing interneurons. Journal of Neurophysiology. 102(6): 3251-3259(Corresponding author).


Si W, Zhang X, Niu Y, Yu H, Lei X, Chen H, Cao X(2010). A novel derivative of xanomeline improves fear cognition in aged mice. Neurosci Lett. 473(2):115-119.


DeAndrade MP, Zhang L, Doroodchi A, Yokoi F, Cheetham CC, Chen HX, Roper SN,Sweatt JD, Li Y(2012) . Enhanced hippocampal long-term potentiation and fear memory inBtbd9 mutant mice. PLoS One. 7(4).


Akakin D, Martinez-Diaz H, Chen HX, Roper SN(2013). Reduced densities ofparvalbumin- and somatostatin-expressing interneurons in experimental corticaldysplasia and heterotopia in early postnatal development. Epilepsy Res. 104(3): 226-233(Corresponding author).


Yokoi F, Chen HX, Dang MT, Cheetham CC, Campbell SL, Roper SN, Sweatt JD, LiY(2015). Behavioral and electrophysiological characterization of Dyt1 heterozygousknockout mice. PLoS One 10(3).


Zhou FW, Fortin JM, Chen HX, Martinez-Diaz H, Chang LJ, Reynolds BA, Roper SN(2015).Functional integration of human neural precursor cells in mouse cortex. PLoS One 10(3).


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